Wednesday, 21 November 2018

Assisted Reproductive Technologies (ART): composite case study and analysis

Photo: Incubator: need to put the fertilized egg in there at body temperature for 5 days!



Abstract:
This paper examines Assisted Reproductive Technologies (ART) through a composite case study. Dilemmas identified include ageing, harms and risks of ART, infertility vs God’s command to procreate, disembodiment of sexuality and begetting, humans using technology to usurp God, when does personhood occur, ‘spare’ embryos, commodification of the donor, surrogate and child, making vs begetting, the selection of a “designer” child, idolatrous expectations on children, and the psychosocial development of the child. I take a precautionary stance towards ART. ART is not very cost-effective and has many risks. Although procreation without sex is not the ideal, ART can be done as a restorative procedure so long as the genetic link between the parents and the child is not disrupted. The “biopsychosocialspiritual” needs of all parties should be addressed. No party should be seen as a commercial commodity. Lives already created should not be destroyed. Jesus is our hope, not the child.



Eve is a 34y.o. single woman who comes in to see me, a General Practitioner, to enquire about egg freezing. She is of Chinese ethnicity and her father, Dan, owns a large multinational company. Her brother, John, is married and has several daughters. John has poor health and his wife is postmenopausal. Dan is keen to get a male heir to the company, as the continuation of the family name is important in the Chinese culture, and places a lot of pressure on Eve to get married and have a child. While Eve is keen to have a child, she never had a boyfriend in her life. As a Christian, she feels highly conflicted. She knows I am also a Christian and wants me to give her my medical, ethical and theological opinions.

Eve faces the dilemma of biological ageing and decline in fertility. Hewlett[1] found that nearly 9/10 young women are confident they could get pregnant in their 40s, but in fact, a woman’s fertility begins to decline at age 27.[2] If Eve does not freeze her eggs now, her egg may no longer be worthwhile freezing, because the response to ovarian stimulation and the quality of the egg is better for those younger than 35 years old.[3] The most cited reason for women to freeze their eggs is the lack of a partner.[4] There are many possibilities about what can happen in the next few years. If Eve finds a partner in the next few years, she is likely to conceive naturally. If she does not, and does not utilise ART, she will miss out on the opportunity to have a child. However, if she uses ART to conceive without a partner, it will be extremely difficult bringing up a child as a single parent. If she utilises the eggs after menopause, she may no longer have enough energy to bring a child up and is at a higher risk of dying before the child grows up.[5]  

Another dilemma is the medical risk and harms of the actual ovulation induction and egg freezing. First, she needs to use hormones to stimulate egg production. Ovarian hyperstimulation syndrome is a rare but dangerous complication of ovarian stimulation.[6] Furthermore, the risk of breast cancer and endometrial cancer following exposure to ovarian stimulation medications is currently inconclusive.[7] Egg collection involves passing a long needle passing through the vaginal wall. Despite the risks of anaesthetic complications, structural damage, excessive bleeding and infections,[8] some women still want to do it “to avoid future regret.”[9] Interestingly, research shows that most women who freeze their eggs never end up utilising them.[10] Mesen et al.[11] concludes that the most cost-effective age for freezing oocytes is 37 years. In reality, the mean age people freeze their eggs is also at 37 years.[12]

Looking at this from principle ethics, although egg freezing is advertised as a way of enhancing women’s reproductive freedom,[13] I do not think Eve can have true autonomy in the procedure because there is not enough known, eg. long-term effects of ARTs on the patient or the child who result from them,[14] for her to be truly informed. There is harm done on her body, so egg freezing goes against the principle of nonmaleficence. There is no beneficence or medical benefit[15] in undergoing this procedure. The possibility for positive consequence will only come if she utilise the eggs. From a justice point of view, ART is not egalitarian.[16] Those who undergo ART are usually socio-economically advantaged.[17] People pay $5,800 for social egg freezing.[18] It is not a medically necessary treatment as most women who freeze their eggs do not have anything medically wrong.[19] It is not possible for the health system, with its limited resources,[20] to fund every person in the world for this procedure. Furthermore, ART takes up a lot of resources and gives a relatively low rate of success as the actual live birth rates per embryo transfer is less than 50%.[21]    

Theologically, egg freezing is not unbiblical. However, theological issues will arise when Eve accesses her eggs to undergo IVF. Eve can do some self-exploration on the topic of IVF, eg. reading books such as Dr Megan Best’s “Fearfully and Wonderfully Made,” to form her own theological opinions first, because there is no point freezing the eggs if she does not think she will proceed with IVF. If she decides to freeze her eggs, I recommend doing it in two years’ time, as her personal circumstances may change later and it is not cost-effective to put her health at risk for something she is highly unlikely to utilise.
Photo: Lab equipments for ART!

Eve decided not to proceed with egg freezing. A year later Eve returns to me. She is now more conflicted about her Christian faith because she had entered into a lesbian relationship with Miriam, a 38y.o. woman. They are both keen to have a child. They are contemplating on whether to impregnate Eve with de-identified donor sperm or to impregnate Miriam with John’s sperm so the offspring will be genetically related to both of them. I believe a reputable fertility specialist is in a better position to give them advice than I am, so I referred them on. Medical assessment reveals that Eve has a congenital uterine malformation and cannot carry a pregnancy. Eve comes back to me depressed and angry. She feels very angry with God, because she cannot control her sexual orientation, and now she finds out she cannot carry a baby!

Infertility often comes as a crisis, because most people just assume they are able to have children when they want to try for one. When they realise they are infertile, they also realise they have no control over what happens.[22] Although infertility is treated largely as a medical or social crisis,[23] it also gives rise to profound emotional and spiritual distress. It is a “biopsychosocialspiritual” crisis! Infertile women may feel part of being a woman is being able to be a mother, and she cannot do what she was made to do.[24] From the Bible, we can see how distressed some women are about infertility. For instance, in Genesis 30:1, Rachel said to Jacob, “give me children or I’ll die!” In 1Samuel 1:7-8, Hanna was provoked by another to the point where she wept and could not eat. Friends and relatives of the childless couples may hold judgemental attitudes and make many assumptions. Professional counselling may be needed to cope with the stresses associated with infertility.[25]

Spiritually, people sometimes describe infertility as the death of a dream, a loss of hope,[26] and even a kind of “dying.” They encounter a deep confrontation of meaning and belief.[27] The question of “Can you honestly say you are content to accept whatever God’s will is?” comes up.[28] Furthermore, Christians who interpret “be fruitful and increase in number (Genesis 1:28)” as a command can feel guilty if they are not able to perform this command. Some Christian go so far as to argue that one has to procreate using whatever means there is available in our current technology.[29] However, not all couples are able to bear children, and it is repeatedly acknowledged in Scripture. Nevertheless, children within marriage are presented as the norm, and it is through them that the image of God is perpetuated (Genesis 5:1).[30] The Roman Catholic teachings say that the life-partnership of marriage is subservient to the procreation of children.[31] Barth[32] insists the opposite is true, that marriage is a life-partnership and does not depend on the coexistence of children to be valid. This is supported by the narrative on the creation of Eve in Genesis 2:18-22.[33]

Some infertile people wonder whether they are being punished by God for their sins. However, we cannot make a simple direct connection between suffering and sin, eg. the man born blind (John 9), and Elizabeth and Zechariah, who were “righteous before God” and yet infertile (Luke 1:6-7).[34] So we should not assume “infertility is punishment on us from God,” nor should we conclude that “God is bound to bless us with fertility if we are obedient, godly Christians.”[35] Meanwhile, the church environment does not help either. People who do not have children often feel “marginalized within faith communities that place a great deal of emphasis on families and family life.” Ryan suggests that “self-acceptance is a critical moment in the spiritual journey through infertility,”[36] and that “transformative spirituality in the face of infertility” is built on an “awareness of the constant companionship of God in the experience of disappointment and despair.”[37] Suffering is inevitable in a fallen world. Although suffering is a test for character, it can destroy us as easily as it can help us grow,[38] so it is important to pray for the strength to accept suffering as part of the obedience to God’s calling as opposed to trying to end suffering at all costs.[39] Some people will eventually have to accept that child-bearing is not God’s current plan for them.[40]

Some view infertility as a medical disease which needs treatment to allow for physical wellbeing. However, the physical impossibility for some people to bear a child due to sterility suggest that reproduction cannot be a universal right, because no-one has the power to make it possible for everyone, [41] and many people even see childlessness as a blessing by choice![42] Furthermore, a ‘rights talk’ is not biblical as children are seen as a gift from God.[43] Psalm 127 reminds us that the ability to bear children is God's gift and subject to God's control. Yet, these days, entrepreneurs see infertility as big business and ART goes beyond just fixing what is broken. Services are provided for those with ‘social infertility’: single parents, same-sex couples, and even those who can have a child but prefers someone else to do the hard work. This sometimes requires the donation of sperm, eggs and wombs![44] There are ART service providers that “cater exclusively for the LGBTI community,” eg. Rainbow Fertility. However, service providers targeting the LGBTI are not necessarily “nonjudgmental.” Stammer[45] points out that “all healthcare professionals, regardless of their spiritual tradition or lack of one, possess beliefs and commitments, which in turn influence their actions.” Personally, I would refer according to reputability.
Photo: The 5 day view of the fertilized egg. It has to become a blastocyst for implantation. 

A few months later, Eve decides to shift her focus on God and end her lesbian relationship with Miriam. She describes another disturbing conflict to me. Miriam is still keen for a child. Miriam is very conflicted as her Orthodox Jew family disowned her because of her homosexuality,[46] and considers a child conceived through donor insemination as a ‘bastard.’ They will not help her in any way.[47] Meanwhile, John has just been diagnosed with a terminal illness, and Dan becomes desperate. Dan offers to give Miriam financial support for the ART treatments and the costs of bringing the child up. However, this is on the condition that Miriam uses John’s sperm, undergoes IVF so she can select for a male child under preimplantation genetic diagnosis (PGD), abort the child if the 18-20 week morphology scan shows abnormalities, and the child is to inherit both his family name and business.

It is not surprising that Eve feels disturbed here. Miriam is being seen by Dan as a reproductive commodity, a cattle whose job is to produce the designer child that Dan desires.[48] The substantial financial reward that Dan offers is a form of coercion.[49] If Miriam accepts the offer, she is essentially selling herself, similar to the women in developing countries who choose to act as surrogates in order to get out of the slums and get their own children educated to the university level.[50] Dan is exploiting Miriam’s vulnerability here. People with intense desire for a child are very vulnerable and can easily become a victim to fraud.[51] Miriam might not notice it but she is paying a big price. Dan is placing Miriam in harm. Miriam can get pregnant with intrauterine insemination (IUI), but Dan wants her to undergo the more invasive IVF so she can get a PGD and select embryos based on gender. PGD for sex-selection is illegal in Australia,[52] so she has to travel to a country where it is legal. However, sex-selective abortions in India, China and South Korea have already been causing major sex ratio distortions due to sexism in these cultures, and Dan is adding to the problem.[53]

Miriam will have an extremely high-risk pregnancy. She is of an advanced maternal age. More than 30% of ART pregnancies turn into a multiple pregnancy which in of itself is high risk.[54] Single ART pregnancies still demonstrate increased rates of perinatal complications.[55] Her child will be at increased risk of major structural birth defects such as cardiac defects, orofacial clefts, oesophageal and anorectal atresia and hypospadias.[56] FINRRAGE (Feminists International Network of Resistance to Reproductive and Genetic Engineering) argues against ART from a feminist position, arguing that techniques for assisting human reproduction bears a striking resemblance to techniques used to facilitate reproduction in livestock. Female animals are turned into machines for producing “superior” animals, reducing the animal to a reproductive commodity.[57] It is the woman that carries the most burdens in ART,[58] and ART treats the women’s body as biological machines that can be manipulated and controlled.[59]

A hotly debated theological issue in ART is the disembodiment of sexuality and begetting. Both male and female has the same unique God-given status as image-bearers, but different sexual roles.[60] Genesis 1:26-28 and 2:23-25 tells us that normal childbearing is a relational process which occurs within the covenantal relationship of marriage.[61] The Catholics believe procreation needs to occur in the context of a loving monogamous marriage through an act of sexual intercourse, and having sex without an intention for procreation is wrong, eg. using contraception is wrong. The Protestants believe that although sexual acts and procreation must occur within the context of a marriage, not every sexual act have to lead to procreation.[62] Some Christians and Jews view semen collection through masturbation as sinful.[63] There are ways to get around masturbation in sperm collection if the pair is husband and wife, eg. using a ‘holy condom’ to collect the sperm during intercourse.[64]

Another reason the Catholics argue against ART is because they view procreation without sex as sinful,[65] and when people seek ways to reproduce asexually, they are using technology to get around God’s original intention for marriage. Protestants tend to vary in their opinions on whether procreation must occur through a sexual act or not. The Tower of Babel narrative describes humanity’s tendency towards using technology to usurp God.[66] Indeed, technology can at times be an instrument of alienation rather than restoration; it can cost people much in time and money and pain and inconvenience, and leave them worse off than they were before.[67] Wyatt[68] believes “the ethics of art restoration” can be practiced, where the restorer is not free to change or improve the masterpiece they are trying to restore, but to follow the artist’s (ie. God’s) original intention, and using IVF to assist an infertile couple to have their own genetically related child is a form of restorative technology.[69]

A question under constant debate in ART is, “When does personhood occur?” Most Christians and embryologists believe that life begins at fertilisation.[70] Many Christians use Psalm 139 to argue for life beginning at the time of an embryo. God had been involved with the psalmist’s life right from the beginning when he was an “embryo.”[71] So this passage reminds us of the wonders of each human life, right from the very beginning when we were still unformed. Other definitions include 14 days, where twinning is no longer possible,[72] implantation,[73] and quickening.[74] Some define it according to viability, the ability to survive outside the womb, which is usually 22+ weeks. Most Western federal courts define this as the time of birth.[75] Some define it as sentience, which is capacity to feel pain, but this includes higher-ordered animals too.[76] Singer[77] is famously known for declaring that “life without consciousness is of no worth at all.” He proposes that the worth of life varies depending on the functioning of the cerebral cortex and recommends “mercy killing” for a life that is “not worth living.”[78]

One’s definition of personhood determines how one argues about “spare” embryos and abortions. “Spare” embryos are those originally produced for IVF procedures which were not used. They are destined to be discarded, so some would ask, “if we bring about their death by using them in research, could we say that nothing is thereby lost?”[79] The utilitarian argument is that the lives saved by research would far outweigh the value of embryonic life lost.[80] If one believes life starts at fertilisation then killing “spare” embryos is unethical. It is hard to see how a Christian ethic that regards others as valuable because they are neighbours whom God has given us to love could accept the purely instrumental use of some neighbours for the sake of others.[81] Another dilemma is the decision about which embryos to keep and which to discard. This decision has to be made within three days after fertilisation. Best[82] is not aware of any method of embryo morphology assessment that has proven to be effective in predicting the viability of IVF embryos. The ‘extended culture’ only gives people two extra days to decide. PGD allows for genetic analysis before the embryo is transferred. Those who believe personhood begins at implantation would see the discarding the embryo prior to embryo transfer as ethical and morally superior to abortion.[83] Likewise, those who believe personhood begins outside the womb would see abortion as ethical.

I take the view that life begins at fertilisation, while we were still “unformed.” So taking a life is unethical, even that of an unimplanted embryo. Each human is made in the image of God and that alone is the reason for the sanctity of life. Therefore, the value of each human life is not calculated in materialistic or functional terms, and the weak and vulnerable ones such as the embryos, fetuses, infants, people with disability, people with dementia and people in the vegetative state should be protected.[84] They are neighbours whom God has given us to love, not to eliminate.[85] There are multiple promises for redemption and commands to defend the defenceless. [86] Destroying a neighbour in an attempt to solve a problem is immoral.[87] Therefore, we should avoid creating “spare” embryos. It is also important to take an eschatological view towards human lives. Wyatt says,[88] “We are treating someone now in the light of what they are going to be… This is why we can still respect and treat with dignity even the most tragically damaged of human beings.”

Dan is placing too much hope in his “designer child.” He is using screening technology for ‘quality control’.[89] The selection of children with certain genotypes is inconsistent with the ideal of parents having unconditional love for their children.[90] To exert such control over the beginning of life is to treat children as commodities.[91] The child being made, not begotten,[92] and begins to resemble product of our wills rather than the offspring of our passion.[93] Our stance towards the child is instrumental.[94] O’Donovan[95] argues that those whom we beget are like us and can be in a relationship of equals with us. Things that we make, by contrast, are in a sense alienated from us. Here, technology is used to impose idolatrous cultural values of the parents onto the very bodies and intellects of their chosen children.[96] The statement “our children are our hope for the future” is a form of idolatry. Jesus is our hope for the future. Our children are destined for suffering and death like the rest of us.[97]

The child who was wanted for all the wrong reasons is pressured to live up to parental expectations and be “the perfect child.”[98] This has profound implications for family relationships and the psychosocial development of the child.[99] The family is one remaining institution where status is given by birth, not earned.[100] With gamete donation and surrogacy, lines of kinship becomes very blurry. Up to five “parents” can be involved: two genetic parents, a gestational mother, two rearing parents.[101] The child can be cut off from either half or all of its genetic heritage.[102] Can the children comprehend, without anxiety, that mothers make babies and give them away for money?[103] A child with clouded genetic heritage has a more difficult time achieving a secure personal identity.[104] This ambiguity can in turn lead to psychosocial harm.[105]

Although ‘third parties’ contributing to reproduction can be found in the Old Testament, eg. Hagar, it is still different from the donor gametes in the modern sense, as the biblical ‘donors’ still had a role in raising the child.[106] In modern days, the gamete donor is involved in child-bearing without the intention of fulfilling their parental responsibilities.[107] Some donor offspring describe feeling such a strong pain of ‘genetic bewilderment’ that they feel angry they were ever born.[108] There should be ethical standards which protect and strengthen positive outcomes for children. Those rearing the child should possess average or adequate psychological and social resources for childrearing.[109] Miriam’s family disowned her so she lacks social support. John, the gamete donor, will die soon. Miriam will be financially dependent on Dan to raise a child. I believe Dan’s offer is unethical as he treats all parties as commodities and the child will have a clouded genetic heritage.

To conclude, I take a precautionary stance towards ART and hold the following views: 1) It is important for those seeking assistance to be made fully aware of the risks of this technology and not hold unrealistic expectations. Social egg freezing is hard to justify as most women do not end up accessing the eggs. ART takes up a lot of resources and gives a relatively low success rate. 2) It is important to address the “biopsychosocialspiritual” needs of the infertile couple and avoid marginalising people who do not have children. Some people will eventually have to accept that childbearing is not part of God’s plans for their lives. 3) Sex and procreation belongs to marriage, but not every act of sex need be for procreation. Although procreating without sex is not the ideal, ART can be done as a restorative procedure so long as the genetic link between the parents and the child is not disrupted. 4) Third party donors and surrogacy should be avoided as children with clouded genetic heritage are more likely to develop psychological problems. 5) No party should be seen as a commercial commodity: no one should be coerced into donating gametes or acting as a surrogate, and the child should not be selected based on “desirable traits”. 6) Life begins at fertilisation, so one should take care not to produce excess embryos, as lives that have already been created need to be protected. 7) Parental resources for childrearing should be assessed and the psychological development of child should be monitored closely. 8) It is important to remember that Jesus is our hope for the future and not place idolatrous expectations on children.


Photo: Jars containing frozen embryos! 

(just in case if you don't know what "composite case study" means - it just means the case is fictional, but based on many real life scenarios)

Bibliography:

Aubusson, Kate. “National guidelines oppose push to allow parents to choose sex of IVF babies.” Sydney Morning Herald, April 20, 2017. Accessed October 14, 2018.  https://www.smh.com.au/healthcare/national-guidelines-oppose-push-to-allow-parents-to-choose-sex-of-ivf-babies-20170420-gvoe6v.html.

Barth, Karl. Church Dogmatics: III.4 The Doctrine of Creation. Edited by G. W. Bromiley and T.F. Torrance. London: T&T Clark, 2009.

Beauchamp, T. L. ‘The “four principles” approach.’ In Principles of Health Care Ethics, edited by R. Gillon, 3-12. Chichester: Wiley, 1994.

Best, Megan. Fearfully and Wonderfully Made: Ethics and the beginning of human life. Kingsford: Matthias Media, 2012.

Burke, Jason. “India’s surrogate mothers face new rules to restrict ‘pot of gold’.” The Guardian, July 30, 2010. Accessed October 14, 2018. http://www.guardian.co.uk/world/2010/jul/30/india-surrogate-mothers-law.

Callahan, Sidney. “The Ethical Challenge of the New Reproductive Technology.”  In On Moral Medicine: Theological Perspectives in Medical Ethics, edited by M. Therese Lysaught et. al., 858-865. Grand Rapids: William B. Eerdmans Publishing Company, 2012. 

Clouser, K. Danner and Bernard Gert. “A Critique of Principlism.” In Meaning and Medicine: A Reader in the Philosophy of Health Care, edited by James Lindermann Nelson and Hilde Lindermann Nelson, 156-166. New York: Routledge, 1999.

DeClaisse-Walford, Nancy, Rolf A. Jacobson, and Beth LaNeel Tanner. The Book of Psalms. Grand Rapids: William B. Eerdmans Publishing Company, 2014.

Encyclical of Paul VI Rome, 25 July 1968, “Humanae Vitae: On the Regulation of Birth.” Accessed October 12, 2018, http://w2.vatican.va/content/paul-vi/en/encyclicals/documents/hf_p-vi_enc_25071968_humanae-vitae.html.

Genea. “Genea’s success rates.” Accessed October 14, 2018. https://www.genea.com.au/assisted-conception/success-rates?gclid=EAIaIQobChMI6tK5uMeF3gIVFHZgCh3nWAxBEAAYASAAEgJc3vD_BwE.

Genea. “Genea Horizon brochure.” Accessed October 14, 2018. https://www.genea.com.au/GEN/media/Genea/PDF/Genea-Horizon-brochure.pdf.

Genea. Your Fertility Journey: brochure for patients. Sydney: Genea, 2017.

Goldingay, John. Psalms Volume 3: Psalms 90-150. Grand Rapids: Baker Academic, 2006.

Hammarberg, Karin et al. “Reproductive experiences of women who cryopreserve oocytes for non-medical reasons.” Human Reproduction 32 (2017): 575-581.

Harris, John. On Cloning. London: Routledge, 2004.

Hauerwas, Stanley. Suffering Presence: Theological Reflections on Medicine, the Mentally Handicapped, and the Church. Notre Dame: University of Notre Dame Press, 1986.

Hewlett, Sylvia Ann. Creating a Life: Professional Women and the Quest for Children. New York: Miramax, 2002.

Hodes-Wertz, B. et al. “What do reproductive-age women who undergo oocyte cryopreservation think about the process as a means to preserve fertility?” Fertility and Sterility 100 (2013): 1343–1349.

IVF Australia. “IVFAustralia success rates.” Accessed October 14, 2018. https://www.ivf.com.au/ivf-success-rates.


Jones, D. Gareth. “Christian Responses to Challenging Developments in Biomedical Science: The Case of In Vitro Fertilisation.” Science and Christian Belief 26 (2014): 143-164.

Lauritzen, Paul. “Whose Bodies? Which Selves? Appeals to Embodiment in Assessments of Reproductive Technology.” In On Moral Medicine: Theological Perspectives in Medical Ethics, edited by M. Therese Lysaught et. al., 850-857. Grand Rapids: William B. Eerdmans Publishing Company, 2012. 

Lerner-Geva, L. J. Rabinovici and B. Lunenfeld. “Ovarian stimulation: is there a long-term risk for ovarian, breast and endometrial cancer?” Women’s Health 6 (2010): 831-839.

Linkeviciute, Alma et al. “Oocyte cryopreservation beyond cancer: tools for ethical reflection.” Journal of Assisted Reproduction and Genetics 32 (2015): 1211-1220.

Matthews, Kenneth A. The American Commentary: Genesis 1-11:26. Nashville: B&H Publishing Group, 1996.

McWhinnie, A. Who am I? Leamington Spa Idreos Education Trust, 2006.

Meilaender, Gilbert. Bioethics: A Primer for Christians. Grand Rapids: William B. Eerdmans Publishing Company, 2013.

Mesen, T.B. et al. “Optimal timing for elective egg freezing.” Fertility and Sterility 103 (2015):1551–1556.


Messer, Neil. Respecting Life: Theology and Bioethics. London: SCM Press, 2011.

O’Donovan, Oliver. Begotten or Made? Oxford: Clarendon Press, 1984.

Panitch, Vida. “Assisted Reproduction and Distributive Justice.” Bioethics 29 (2015): 108-117.

Pritchard, Natasha et al. “Characteristics and circumstances of women in Australia who cryopreserved their oocytes for non-medical indications.” Journal of Reproductive and Infant Psychology 35 (2017): 108-118.


Rae, Scott B. and Paul M. Cox. Bioethics: A Christian Approach in a Pluralistic Age. Grand Rapids: William B. Eerdmans Publishing Company, 1999.

Reddy, U.M. et al. “Infertility, assisted reproductive technology, and adverse pregnancy outcomes Executive summary of a National Institute of Child Health and Human Development workshop.” Obstetrics and Gynaecology 109 (2007): 967-977.

Reefhuis, J. et al. “Assisted reproductive technology and major structural birth defects in the United States.” Human Reproduction 24 (2009): 360-366.


Ryan, Maura A. “Faith and Infertility.” In On Moral Medicine: Theological Perspectives in Medical Ethics, edited by M. Therese Lysaught et. al., 865-869. Grand Rapids: William B. Eerdmans Publishing Company, 2012.

Schenker, Joseph G. “Human reproduction: Jewish perspectives.” Gynaecological Endocrinology 29 (2013): 945-948.

Sharp, Richard R. et al. “Moral attitudes and beliefs among couples pursuing PGD for sex selection.” Reproductive BioMedicine Online 21 (2010): 838-847.

Singer, Peter. Rethinking Life and Death. New York: St Martin’s Griffin, 1994.

Sloane, Andrew. Vulnerability and Care: Christian Reflections on the Philosophy of Medicine. London: Bloomsbury T&T Clark, 2016.

Sloane, Andrew. At home in a strange land: using the Old Testament in Christian ethics. Peabody: Hendrickson Publishers, 2008.

Stammers, Trevor. “The NHS – No Place for Conscience.” Catholic Medical Quarterly 63 (2013). Accessed October 6, 2018. http://www.cmq.org.uk/CMQ/2013/Aug/nhs_no_place_for_conscience.html.


Tsafrir, A. et al. “Ovarian stimulation for oocyte cryopreservation for prevention of age-related fertility loss: one in five is a low responder.” Gynecological Endocrinology 31(2015):779–782.

Verhey, Allen. “A.R.T., Ethics, and the Bible.” In On Moral Medicine: Theological Perspectives in Medical Ethics, edited by M. Therese Lysaught et. al., 870-893. Grand Rapids: William B. Eerdmans Publishing Company, 2012.

Whittaker, Andrew. “Media debates and ‘ethical publicity’ on social sex selection through preimplantation genetic diagnosis (PGD) technology in Australia.” Culture, Health & Sexuality 17 (2015): 962-976.

Wyatt, John. Matters of Life & Death: Human dilemmas in the light of the Christian faith. Nottingham: IVP, 2009.



[1] Sylvia Ann Hewlett, Creating a Life: Professional Women and the Quest for Children (New York: Miramax, 2002).
[2] Megan Best, Fearfully and Wonderfully Made: Ethics and the beginning of human life (Kingsford: Matthias Media, 2012), 270.
[3] A. Tsafrir, et al. “Ovarian stimulation for oocyte cryopreservation for prevention of age-related fertility loss: one in five is a low responder,” Gynecological Endocrinology 31(2015):779.
[4] B. Hodes-Wertz, et al, “What do reproductive-age women who undergo oocyte cryopreservation think about the process as a means to preserve fertility?” Fertility and Sterility 100 (2013): 1346; Karin Hammarberg, et al. “Reproductive experiences of women who cryopreserve oocytes for non-medical reasons,” Human Reproduction 32 (2017): 576. This is contrary to the stereotype of women deliberately delaying childbearing to advance their careers.
[5] Hammarberg, et al. “Reproductive experiences of women who cryopreserve oocytes for non-medical reasons,” 579.
[6] Best, Fearfully and Wonderfully Made, 334.
[7] L. Lerner-Geva, J. Rabinovici and B. Lunenfeld. “Ovarian stimulation: is there a long-term risk for ovarian, breast and endometrial cancer?” Women’s Health 6 (2010): 831-839.
[8] Genea. Your Fertility Journey: brochure for patients (Sydney: Genea, 2017), 6-7.
[9] Natasha Pritchard, et al. “Characteristics and circumstances of women in Australia who cryopreserved their oocytes for non-medical indications.” Journal of Reproductive and Infant Psychology 35 (2017): 114.
[10] Hammarberg, et al. “Reproductive experiences of women who cryopreserve oocytes for non-medical reasons,” 580.
[11] T.B. Mesen, et al. “Optimal timing for elective egg freezing,” Fertility and Sterility 103 (2015):1551.
[12] Hammarberg, et al. “Reproductive experiences of women who cryopreserve oocytes for non-medical reasons,” 577.
[13] Alma Linkeviciute, et al. “Oocyte cryopreservation beyond cancer: tools for ethical reflection,” Journal of Assisted Reproduction and Genetics 32 (2015): 1218.
[14] Scott B. Rae, and Paul M. Cox. Bioethics: A Christian Approach in a Pluralistic Age (Grand Rapids: William B. Eerdmans Publishing Company, 1999), 54; Genea. Your Fertility Journey, 21. Even the Genea brochure gives this warning.
[15] Tom L. Beauchamp, “The ‘Four Principles’ Approach,” in Meaning and Medicine: A Reader in the Philosophy of Health Care, ed. James Lindermann Nelson and Hilde Lindermann Nelson (New York: Routledge, 1999), 148.
[16] K. Danner Clouser, and Bernard Gert. “A Critique of Principlism,” in Meaning and Medicine: A Reader in the Philosophy of Health Care, ed. James Lindermann Nelson and Hilde Lindermann Nelson (New York: Routledge, 1999), 166.
[17] Hammarberg, et al. “Reproductive experiences of women who cryopreserve oocytes for non-medical reasons,” 577.
[18] “Fertility and IVF costs,” Genea, accessed October 14, 2018, https://www.genea.com.au/costs.;
“Genea Horizon brochure,” Genea, accessed October 14, 2018.  https://www.genea.com.au/GEN/media/Genea/PDF/Genea-Horizon-brochure.pdf. There had been a price drop. It used to be $10,000 until the end of 2017.
[19] Vida Panitch, “Assisted Reproduction and Distributive Justice,” Bioethics 29 (2015): 115.
[20] John Wyatt, Matters of Life & Death: Human dilemmas in the light of the Christian faith (Nottingham: IVP, 2009), 39.
[21] “Genea’s success rates,” Genea, accessed October 14, 2018, https://www.genea.com.au/assisted-conception/success-rates?gclid=EAIaIQobChMI6tK5uMeF3gIVFHZgCh3nWAxBEAAYASAAEgJc3vD_BwE.; “IVFAustralia success rates,” IVF Australia, accessed October 14, 2018, https://www.ivf.com.au/ivf-success-rates.
[22] Best, Fearfully and Wonderfully Made, 263.
[23] Maura A. Ryan, “Faith and Infertility,” in On Moral Medicine: Theological Perspectives in Medical Ethics, ed. M. Therese Lysaught et. al. (Grand Rapids: William B. Eerdmans Publishing Company, 2012), 866.
[24] Best, Fearfully and Wonderfully Made, 290.
[25] Ibid., 288.
[26] Ibid., 291.
[27] Ryan, “Faith and Infertility,” 866.
[28] Best, Fearfully and Wonderfully Made, 291.
[29] D. Gareth Jones, “Christian Responses to Challenging Developments in Biomedical Science: The Case of In Vitro Fertilisation,” Science and Christian Belief 26 (2014): 155.
[30] Best, Fearfully and Wonderfully Made, 61.
[31] “Humanae Vitae: On the Regulation of Birth,” Encyclical of Paul VI, Rome, 25 July 1968, accessed October 12, 2018, http://w2.vatican.va/content/paul-vi/en/encyclicals/documents/hf_p-vi_enc_25071968_humanae-vitae.html.
[32] Karl Barth, Church Dogmatics: III.4 The Doctrine of Creation, ed. G. W. Bromiley and T.F. (Torrance. London: T&T Clark, 2009), 181. (188 of original edition)
[33] Best, Fearfully and Wonderfully Made, 61.
[34] Ibid., 267.
[35] Ibid., 268.
[36] Ryan, “Faith and Infertility,” 868.
[37] Ibid., 869.
[38] Stanley Hauerwas, Suffering Presence: Theological Reflections on Medicine, the Mentally Handicapped, and the Church (Notre Dame: University of Notre Dame Press, 1986), 26.
[39] Messer, Respecting Life: Theology and Bioethics (London: SCM Press, 2011), 201.
[40] Best, Fearfully and Wonderfully Made, 273.
[41] Ibid., 272.
[42] Panitch, “Assisted Reproduction and Distributive Justice,” 112.
[43] Best, Fearfully and Wonderfully Made, 272.
[44] Ibid., 326.
[45] Trevor Stammers, “The NHS – No Place for Conscience,” Catholic Medical Quarterly 63 (2013), accessed October 6, 2018. http://www.cmq.org.uk/CMQ/2013/Aug/nhs_no_place_for_conscience.html.
[46] Joseph G. Schenker, “Human reproduction: Jewish perspectives,” Gynaecological Endocrinology 29 (2013): 946. As homosexuality is strictly forbidden (Lev. 18; 22; 20:13) in Orthodox Judaism.
[47] Schenker, “Human reproduction: Jewish perspectives,” 947.
[48] Paul Lauritzen, “Whose Bodies? Which Selves? Appeals to Embodiment in Assessments of Reproductive Technology,” in On Moral Medicine: Theological Perspectives in Medical Ethics, ed. M. Therese Lysaught et. al. (Grand Rapids: William B. Eerdmans Publishing Company, 2012), 851. 
[49] Best, Fearfully and Wonderfully Made, 338.
[50] Jason Burke, “India’s surrogate mothers face new rules to restrict ‘pot of gold’,” The Guardian, July 30, 2010, Accessed October 14, 2018, http://www.guardian.co.uk/world/2010/jul/30/india-surrogate-mothers-law.
[51] Best, Fearfully and Wonderfully Made, 288.
[52] Kate Aubusson, “National guidelines oppose push to allow parents to choose sex of IVF babies,” Sydney Morning Herald, April 20, 2017, accessed October 14, 2018.  https://www.smh.com.au/healthcare/national-guidelines-oppose-push-to-allow-parents-to-choose-sex-of-ivf-babies-20170420-gvoe6v.html.
[53] Andrew Whittaker, “Media debates and ‘ethical publicity’ on social sex selection through preimplantation genetic diagnosis (PGD) technology in Australia,” Culture, Health & Sexuality 17 (2015): 965.
[54] Best, Fearfully and Wonderfully Made, 385.
[55] U.M. Reddy, et al. “Infertility, assisted reproductive technology, and adverse pregnancy outcomes Executive summary of a National Institute of Child Health and Human Development workshop,” Obstetrics and Gynaecology 109 (2007): 967-977.
[56] J. Reefhuis, et al. “Assisted reproductive technology and major structural birth defects in the United States,” Human Reproduction 24 (2009): 360-366.
[57] Lauritzen, “Whose Bodies?” 851. 
[58] Richard R. Sharp, et al. “Moral attitudes and beliefs among couples pursuing PGD for sex selection,” Reproductive BioMedicine Online 21 (2010): 843.
[59] Lauritzen, “Whose Bodies?” 852.
[60] Kenneth A. Matthews, The American Commentary: Genesis 1-11:26 (Nashville: B&H Publishing Group, 1996), 173.
[61] Andrew Sloane, At home in a strange land: using the Old Testament in Christian ethics (Peabody: Hendrickson Publishers, 2008), 215.
[62] Allen Verhey, “A.R.T., Ethics, and the Bible,” in On Moral Medicine: Theological Perspectives in Medical Ethics, ed. M. Therese Lysaught et. al. (Grand Rapids: William B. Eerdmans Publishing Company, 2012), 887.
[63] Schenker, “Human reproduction: Jewish perspectives,” 948.
[64] Best, Fearfully and Wonderfully Made, 331. A condom with a pinhole in the end.
[65] Lauritzen, “Whose Bodies?” 853.
[66] Wyatt, Matters of Life & Death, 79.
[67] Andrew Sloane, Vulnerability and Care: Christian Reflections on the Philosophy of Medicine (London: Bloomsbury T&T Clark, 2016), 138.
[68] Wyatt, Matters of Life & Death, 99.
[69] Ibid., 103.
[70] Best, Fearfully and Wonderfully Made, 34-35.
[71] John Goldingay, Psalms Volume 3: Psalms 90-150 (Grand Rapids: Baker Academic, 2006), 633; Nancy DeClaisse-Walford, Rolf A. Jacobson, and Beth LaNeel Tanner. The Book of Psalms (Grand Rapids: William B. Eerdmans Publishing Company, 2014), 965. The term translated as “embryo” is a hapax legomenon, with a meaning closer to “unshaped form.”
[72] Warnock committee 1984, UK Parliament.
[73] Many O&G specialists.
[74] Medieval writers.
[75] Best, Fearfully and Wonderfully Made, 34-35.
[76] L.W. Sumner and Peter Singer and some animal rights activists
[77] Peter Singer, Rethinking Life and Death (New York: St Martin’s Griffin, 1994), 190.
[78] Wyatt, Matters of Life & Death, 45-46. Wyatt coins the term “corticalism” to describe Singer’s discrimination of people according to their cortex.
[79] Gilbert Meilaender, Bioethics: A Primer for Christians (Grand Rapids: William B. Eerdmans Publishing Company, 2013), 120.
[80] John Harris, On Cloning (London: Routledge, 2004), 143.
[81] Messer, Respecting Life, 126.
[82] Best, Fearfully and Wonderfully Made, 347.
[83] Whittaker, “Media debates and ‘ethical publicity’ on social sex selection through preimplantation genetic diagnosis (PGD) technology in Australia,” 965.
[84] Wyatt, Matters of Life & Death, 60.
[85] Messer, Respecting Life, 121.
[86] Wyatt, Matters of Life & Death, 79.
[87] Messer, Respecting Life, 112.
[88] Wyatt, Matters of Life & Death, 273.
[89] Ibid., 36-37.
[90] Whittaker, “Media debates and ‘ethical publicity’ on social sex selection through preimplantation genetic diagnosis (PGD) technology in Australia,” 965; Messer, Respecting Life, 98.
[91] Sloane, At home in a strange land, 215.
[92] Meilaender, Bioethics, 13.
[93] Ibid., 16.
[94] Messer, Respecting Life, 98.
[95] Oliver O’Donovan, Begotten or Made? (Oxford: Clarendon Press, 1984), 1.
[96] Sloane, At home in a strange land, 215.
[97] Verhey, “A.R.T., Ethics, and the Bible,” 892.
[98] Sidney Callahan, “The Ethical Challenge of the New Reproductive Technology,” in On Moral Medicine: Theological Perspectives in Medical Ethics, ed. M. Therese Lysaught et. al. (Grand Rapids: William B. Eerdmans Publishing Company, 2012), 863.
[99] Whittaker, “Media debates and ‘ethical publicity’ on social sex selection through preimplantation genetic diagnosis (PGD) technology in Australia,” 965.
[100] Callahan, “The Ethical Challenge of the New Reproductive Technology,” 861.
[101] Meilaender, Bioethics, 11.
[102] Callahan, “The Ethical Challenge of the New Reproductive Technology,” 861.
[103] Ibid., 864.
[104] Ibid., 863.
[105] Messer, Respecting Life, 87.
[106] Best, Fearfully and Wonderfully Made, 364.
[107] Best, Fearfully and Wonderfully Made, 365.
[108] A. McWhinnie, Who am I? (Leamington Spa Idreos Education Trust, 2006).
[109] Callahan, “The Ethical Challenge of the New Reproductive Technology,” 859.

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